An adjunctive antidepressant nutraceutical combination in treating major depression: Study protocol, and clinical considerations. Issue 1 (April 2015)

• Record Type: Journal Article
• Authors: Sarris, Jerome; Stough, Con; Bousman, Chad; Murphy, Jenifer; Savage, Karen; Smith, Deidre J.; Menon, Ranjit; Chamoli, Suneel; Oliver, Georgina; Berk, Michael; Byrne, Gerard J.; Ng, Chee; Mischoulon, David
• Is Part Of: Advances in integrative medicine. Volume 2:Issue 1(2015:Jan.)
• Page Start: 49
• Page End: 55
• Publication Date: 2015-04
• Subjects: Integrative medicine -- Periodicals; Alternative medicine -- Periodicals; Integrative Medicine -- Periodicals; Alternative medicine; Integrative medicine; Periodicals; 615.505
• DOI: 10.1016/j.aimed.2015.02.001
• Languages: English
• ISSNs: 2212-9588

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <p id="spar0005">Current treatment for major depressive disorder (MDD), a prevalent and disabling mental illness, is inadequate, with two-thirds of people treated with first-line antidepressants not achieving remission. MDD is for many a chronic condition, often requiring multiple treatment attempts, thus development of additional interventions is urgently required. An emerging approach to improve non-response to antidepressants is the use of adjunctive nutraceuticals. The pathophysiology of MDD is considered to involve a range of abnormalities (monoamine impairment, neuro-endocrinological changes, reduced brain-derived neurotrophic factor, and cytokine alterations). By targeting an array of these key neurobiological pathways via specific nutraceuticals (S-adenosyl methionine; [SAMe], 5-HTP [active tryptophan], folinic acid [active folic acid], omega-3 fatty acids, and zinc), there is the potential to provide a more comprehensive therapeutic biological approach to treat depression. We are currently conducting a National Health and Medical Research Council funded study in Australia (APP1048222). The clinical trial is phase II/III, multi-site, 3-arm, 8-week, randomised, double-blind, placebo-controlled study using SAMe + folinic acid versus a combination nutraceutical (SAMe, 5-HTP, folinic acid, omega-3, and zinc) or matching placebo in 300 currently depressed participants with diagnosed MDD who are non-responsive to current antidepressants (ANZCTR, protocol number: 12613001300763). The results may provide evidence for a novel adjunctive neurobiological approach for treating depression.</p> </sec> </abstract>