How the flexibility of human histone deacetylases influences ligand binding: an overview. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Deschamps, Nathalie; Simões-Pires, Claudia Avello; Carrupt, Pierre-Alain; Nurisso, Alessandra
• Is Part Of: Drug discovery today. Volume 20:Issue 6(2015)
• Page Start: 736
• Page End: 742
• Publication Date: 2015-06
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2015.01.004
• Languages: English
• ISSNs: 1359-6446

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">This review covers the flexibility events occurring within the human zinc-dependent HDACs.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The therapeutic importance of the discovery of new HDAC modulators is emphasized.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Both mass and one-off movements associated to each HDAC isoform are described and illustrated.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Key structural elements for the design of novel HDAC-selective modulators are highlighted.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">A brief overview on the computational methods used for studying flexibility is given.</p> </list-item> </list> </p> </sec> </abstract>