Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Zhang, Zheng Z.; Hsieh, Chih-Lin; Okitsu, Cindy Yen; Han, Li; Yu, Kefei; Lieber, Michael R.
• Is Part Of: Molecular immunology. Volume 66:Issue 2(2015:Aug.)
• Page Start: 284
• Page End: 289
• Publication Date: 2015-08
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.04.005
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The CpG motif is rare within mammalian IgH class switch recombination repeats.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Two CpG sites per 80 bp synthetic Sα switch repeat induces methylation at the Iα, resulting in lower transcription.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">CpG sites within the repetitive Sα region trigger DNA methylation around the promoter.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Ig switch repeats evolved to have few CpG sites to avoid suppression of the promoter.</p> </list-item> </list> </p> </sec> </abstract>