A conserved WW domain-like motif regulates invariant chain-dependent cell-surface transport of the NKG2D ligand ULBP2. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Uhlenbrock, Franziska; van Andel, Esther; Andresen, Lars; Skov, Søren
• Is Part Of: Molecular immunology. Volume 66:Issue 2(2015:Aug.)
• Page Start: 418
• Page End: 427
• Publication Date: 2015-08
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.04.022
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Identification of a WW domain-like motif in the primary protein sequence of NKG2D ligands ULBP1-6 but not in the related MICA/B.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The WW domain-like motif is crucial for the cell-surface transport of the NKG2D ligand ULBP2.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">WW domain-like motif is required for an invariant chain-dependent cell-surface transport of ULBP2.</p> </list-item> </list> </p> </sec> </abstract>