Enhanced and durable protective immune responses induced by a cocktail of recombinant BCG strains expressing antigens of multistage of Mycobacterium tuberculosis. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Liang, Jinping; Teng, Xindong; Yuan, Xuefeng; Zhang, Ying; Shi, Chunwei; Yue, Tingting; Zhou, Lei; Li, Jianrong; Fan, Xionglin
• Is Part Of: Molecular immunology. Volume 66:Issue 2(2015:Aug.)
• Page Start: 392
• Page End: 401
• Publication Date: 2015-08
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.04.017
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0060"> <list id="lis0010"> <list-item id="lsti0005"> <label></label> <p id="par0005">ABX overexpressing multistage antigens induces better protection against primary tuberculosis infection over BCG and individual rBCGs.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">ABX elicits antigen-specific cellular and humoral immunity.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">ABX enhances antigen-specific CTL effects and memory T cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Recombinant BCG cocktail strategy provides a novel platform to improve the efficacy of BCG.</p> </list-item> </list> </p> </sec> </abstract>