A Brucella melitensis M5-90 wboA deletion strain is attenuated and enhances vaccine efficacy. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Li, Zhi-Qiang; Shi, Jing-Xue; Fu, Wen-Dong; Zhang, Yu; Zhang, Jing; Wang, Zhen; Li, Tian-Sen; Chen, Chuang-Fu; Guo, Fei; Zhang, Hui
• Is Part Of: Molecular immunology. Volume 66:Issue 2(2015:Aug.)
• Page Start: 276
• Page End: 283
• Publication Date: 2015-08
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.04.004
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0075"> <list id="lis0010"> <list-item id="lsti0005"> <label></label> <p id="par0005">The M5-90Δ<italic>wboA</italic> has low virulence in macrophages and mice.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The M5-90Δ<italic>wboA</italic> can elicit an anti-<italic>Brucella</italic>-specific IgG response.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">M5-90Δ<italic>wboA</italic> immunizations induce a cellular response.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">M5-90Δ<italic>wboA</italic> immunizations induces protection against <italic>B. melitensis</italic> challenge.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">M5-90Δ<italic>wboA</italic> could be a potential DIVA vaccine.</p> </list-item> </list> </p> </sec> </abstract>