Characterizing the inhibitory action of zinc oxide nanoparticles on allergic-type mast cell activation. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Feltis, B.N.; Elbaz, A.; Wright, P.F.A.; Mackay, G.A.; Turney, T.W.; Lopata, A.L.
• Is Part Of: Molecular immunology. Volume 66:Issue 2(2015:Aug.)
• Page Start: 139
• Page End: 146
• Publication Date: 2015-08
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.02.021
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Mast cell degranulation can be inhibited by ZnO nanoparticles.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">This inhibition was nanoparticle size and dispersion dependent.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">ZnO nanoparticles had higher cytotoxicity to cancerous cells (RBL-2H3) compared to primary mast cells (BMMCs).</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">TiO₂ nanoparticles slightly increased mast cell degranulation.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">These nanoscale enhancements in ZnO bioactivity of may lead to the development of novel anti-allergic therapeutics.</p> </list-item> </list> </p> </sec> </abstract>