Identification and expression analysis of two interleukin-23α (p19) isoforms, in rainbow trout Oncorhynchus mykiss and Atlantic salmon Salmo salar. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Jiang, Yousheng; Husain, Mansourah; Qi, Zhitao; Bird, Steve; Wang, Tiehui
• Is Part Of: Molecular immunology. Volume 66:Issue 2(2015:Aug.)
• Page Start: 216
• Page End: 228
• Publication Date: 2015-08
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.03.014
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Two p19 loci (p19a and p19b) exist in salmonids, being trout p19b a processed pseudogene.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Salmonid p19 genes possess a conserved four exon/three intron organisation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Salmonid p19 gene may be regulated by upstream ATGs and mRNA instability motifs.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Trout p19a expression is induced by bacterial and viral infections and by PAMPs.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">IL-1β may induce IL-23 production by up-regulation of p19 and p40 in HK macrophages.</p> </list-item> </list> </p> </sec> </abstract>