Antibodies reactive to cleaved sites in complement proteins enable highly specific measurement of soluble markers of complement activation. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Blom, Anna M.; Österborg, Anders; Mollnes, Tom E.; Okroj, Marcin
• Is Part Of: Molecular immunology. Volume 66:Issue 2(2015:Aug.)
• Page Start: 164
• Page End: 170
• Publication Date: 2015-08
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.02.029
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We generated antibodies against 5 aa-long linear neoepitopes in C4d and C5b.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The antibodies specifically recognize activated complement components.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Measurement of C4d and TCC allows follow up of systemic complement activation.</p> </list-item> </list> </p> </sec> </abstract>