Intracerebral hemorrhage at young age: long‐term prognosis. (8th April 2015)

• Record Type: Journal Article
• Authors: Koivunen, R.‐J.; Tatlisumak, T.; Satopää, J.; Niemelä, M.; Putaala, J.
• Is Part Of: European journal of neurology. Volume 22:Number 7(2015:Jul.)
• Page Start: 1029
• Page End: 1037
• Publication Date: 2015-04-08
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12704
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" id="ene12704-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12704-sec-0001" sec-type="section"> <title>Background and purpose</title> <p>Intracerebral hemorrhage (ICH) is a devastating disorder associated with dismal outcomes. The long‐term mortality and functional outcome of ICH in young patients was studied – areas so far poorly investigated.</p> </sec> <sec id="ene12704-sec-0002" sec-type="section"> <title>Methods</title> <p>A follow‐up study was performed on a cohort of patients. Clinical and imaging data on ICH patients aged 16–49 were retrospectively obtained and linked with a nationwide cause‐of‐death register. The modified Rankin Scale (mRS) was evaluated for 30‐day survivors at a visit 9.7 (7.0–12.0) years after ICH onset. Independent factors associated with mortality and unfavorable functional outcome (mRS 2–5) were sought by multivariate analysis.</p> </sec> <sec id="ene12704-sec-0003" sec-type="section"> <title>Results</title> <p>Amongst the 268 1‐month survivors, 1‐year survival was 98.1% [95% confidence interval (CI) 96.2%–100%], 5‐year survival 93.2% (89.3%–97.1%) and 10‐year survival 88.8% (84.9%–92.7%). After adjustment for age and intraventricular hematoma extension, male sex [odds ratio (OR) 3.36, 95% CI 1.28–8.80] and diabetes (OR 2.64, 1.01–6.89) were associated with increased mortality. Unfavorable functional outcome emerged in 49%. After adjustment for confounders, age (OR 1.09 per 1 year, 95% CI 1.03–1.15), initial stroke severity (1.17 per one National Institutes of Health Stroke Scale score point, 1.08–1.27) and intraventricular hemorrhage (3.26, 1.11–9.55) were associated with unfavorable functional outcome.</p> </sec> <sec id="ene12704-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Of every 10 survivors of acute phase ICH at a young age, one died within 10 years after onset, male sex and diabetes being associated with increased mortality. Half the survivors did not achieve a favorable functional outcome, which was predicted by increasing age, initial stroke severity and intraventricular hemorrhage.</p> </sec> </abstract>