Lactic Acidosis After Cardiac Transplantation. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Nixon, Jennifer L.; Kfoury, Abdallah G.; McCubrey, Raymond; Brunisholz, Kim; Bair, Tami; Balling, Kyle D.; Budge, Deborah; Doty, John; Rasmusson, Brad; Reid, Bruce; Smith, Hildegard; Thomsen, George; Goddard, Mark; Alharethi, Rami
• Is Part Of: Transplantation. Volume 99:Issue 6(2015)
• Publication Date: 2015-06
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/TP.0000000000000508
• Languages: English
• ISSNs: 0041-1337

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background</title> <p>Lactic acidosis (LA) frequently occurs after heart transplantation (HTx). It is hypothesized to be related to inotropic support or metabolic derangements from chronic heart failure. As such, restoring hemodynamic stability with mechanical circulatory support before HTx should mitigate this problem. Our aim was to evaluate the incidence and outcomes of LA after HTx.</p> </sec> <sec> <title>Methods</title> <p>We evaluated HTx recipients January 2000 to May 2011. Post-HTx outcomes included graft dysfunction, length of intensive care unit stay, length of hospital stay, inotropic support, and survival.</p> </sec> <sec> <title>Results</title> <p>Of 143 eligible patients, 98.6% had LA, 67% severe, after HTx. Data were analyzed based on the severity of LA. Time to peak lactate, intensive care unit stay, length of hospital stay, peak glucose, inotropic dose, graft dysfunction, and survival after HTx were similar between groups. Statistically significant differences included pretransplant support (25.6% mechanical circulatory support in nonsevere vs. 44.9% severe LA), hospitalization at the time of HTx (37.2% vs. 21.4%), glucose at the time of peak lactate (182.88 ± 69.80 vs. 221.31 ± 56.91), ischemic time (187.4 ± 63.1 vs. 215.5 ± 68.1), and duration of inotrope.</p> </sec> <sec> <title>Conclusion</title> <p>Severe LA is common after HTx, though it appears to be transient and benign. Mechanical circulatory support after HTx does not prevent LA. High lactate levels are associated with longer ischemic times, longer duration of inotrope, and correspond with higher glucose levels. The underlying mechanism is yet to be satisfactorily elucidated.</p> </sec> </abstract>