An Elevated Percentage of Reticulated Platelet Is Associated With Increased Mortality in Septic Shock Patients. Issue 19 (May 2015)

• Record Type: Journal Article
• Authors: Wu, Qin; Ren, Jianan; Hu, Dong; Jiang, Pengjun; Li, Guanwei; Anjum, Nadeem; Wang, Gefei; Gu, Guosheng; Chen, Jun; Wu, Xiuwen; Liu, Song; Li, Yuan; Zhao, Yunzhao; Li, Jieshou; Tan., Lionel
• Is Part Of: Medicine. Volume 94:Issue 19(2015)
• Publication Date: 2015-05
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000814
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>Microcirculatory changes and coagulation disturbances are thought to play a key role in sepsis. Some evidence suggests that the percentage of reticulated platelets (RP%) may be a valuable and cost-effective sepsis screening parameter. This was a prospective study in surgical patients to investigate the potential value of RP% as a predictor of mortality in septic shock patients.</p> <p>This was a prospective study conducted in a surgical critical care center of a Chinese tertiary care hospital. Consecutive septic shock patients were enrolled at admission. Age- and sex-matched non-septic patients were recruited as control patients. RP% was determined by flow cytometry in 68 septic shock patients and 68 controls.</p> <p>Compared with survivors, septic patients who died presented with a significantly higher RP% (<italic>P</italic> < 0.001). The area under the receiver-operating characteristic curve for the RP% association with mortality was 0.867 (95 % CI 0.780–0.953, <italic>P</italic> < 0.001). Kaplan–Meier survival curves showed that mortality risk was significantly different when patients were stratified based on RP% (<italic>P</italic> < 0.001). This association was preserved in a multi-logistic regression analysis that included clinical confounders (<italic>P</italic> < 0.014).</p> <p>This prospective study demonstrates that increased RP% identifies septic shock patients who have a high risk of death. RP% has the potential to act as a marker for patient stratification in future clinical trials.</p> </sec> </abstract>