Acute Inflammatory Biomarker Profiles Predict Depression Risk Following Moderate to Severe Traumatic Brain Injury. Issue 3 (May 2015)

• Record Type: Journal Article
• Authors: Juengst, Shannon B.; Kumar, Raj G.; Failla, Michelle D.; Goyal, Akash; Wagner, Amy Kathleen; Bell, Jeneita M.; Taylor, Christopher A.; Breiding, Matthew J.; Caplan, Bruce; Bogner, Jennifer; Brenner, Lisa
• Is Part Of: Journal of head trauma rehabilitation. Volume 30:Issue 3(2015:May/Jun.)
• Publication Date: 2015-05
• Subjects: Brain damage -- Patients -- Rehabilitation -- Periodicals; Brain damage -- Periodicals; 617.4810443
• DOI: 10.1097/HTR.0000000000000031
• Languages: English
• ISSNs: 0885-9701

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective:</title> <p>To examine whether acute inflammation profiles predict posttraumatic depression (PTD) risk 6 and 12 months after traumatic brain injury.</p> </sec> <sec> <title>Setting:</title> <p>University-affiliated level 1 trauma center and community.</p> </sec> <sec> <title>Participants:</title> <p>Adults with moderate to severe traumatic brain injury (acute serum levels: <italic>n</italic> = 50; acute cerebrospinal fluid (CSF) levels: <italic>n</italic> = 41).</p> </sec> <sec> <title>Design:</title> <p>Prospective cohort study.</p> </sec> <sec> <title>Main Measures:</title> <p>Patient Health Questionnaire; inflammatory biomarkers (interleukin [IL]-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, tumor necrosis factor α, soluble vascular adhesion molecule [sVCAM-1], soluble intracellular adhesion molecule [sICAM-1], soluble Fas [sFAS]).</p> </sec> <sec> <title>Results:</title> <p>Higher levels of acute CSF cytokine surface markers (sVCAM-1, sICAM-1, and sFAS) in an inflammatory biomarker risk (IBR) score were associated with a 3.920-fold increase in the odds of developing PTD at 6 months (95% confidence interval: 1.163-8.672). Having sICAM-1, sVCAM-1, or sFAS above the 75th percentile had a positive predictive value of 85.7% for PTD risk at 6 months. An IBR score including inflammatory biomarkers IL-7 and IL-8 showed a trending association with 12-month PTD risk (odds ratio = 3.166, 95% confidence interval: 0.936-10.708).</p> </sec> <sec> <title>Conclusion:</title> <p>Acute CSF IBR scores show promise for identifying individuals at risk for PTD. Further research should assess acute CSF inflammatory biomarkers' relationships to chronic inflammation as a mechanism of PTD and should explore anti-inflammatory treatments for PTD, as well as prevention and screening protocols, and link inflammatory biomarkers to symptom tracking.</p> </sec> </abstract>