Isolated Port-Site Metastases After Minimally Invasive Hysterectomy for Endometrial Cancer. Issue 5 (June 2015)

• Record Type: Journal Article
• Authors: Grant, Jonathan Douglas; Garg, Amit K.; Gopal, Ramesh; Soliman, Pamela T.; Jhingran, Anuja; Eifel, Patricia J.; Klopp, Ann H.
• Is Part Of: International journal of gynecological cancer. Volume 25:Issue 5(2015:Jun.)
• Publication Date: 2015-06
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000000424
• Languages: English
• ISSNs: 1048-891X

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective</title> <p>The management and prognosis of isolated port-site metastases after laparoscopic surgery for endometrial cancer is poorly understood and rarely described in the literature. We report a series of cases treated with radiotherapy to better characterize outcomes in these patients.</p> </sec> <sec> <title>Methods</title> <p>We retrospectively reviewed medical records of patients with endometrial cancer who developed isolated port-site metastases and were treated with radiation therapy at MD Anderson Cancer Center from 1996 to 2013. Seven patients met these criteria for whom treatment and outcome data were collected.</p> </sec> <sec> <title>Results</title> <p>The median interval from initial surgery to port-site recurrence was 15 months. Recurrent tumor size varied from 0.5 to 9 cm as measured on axial imaging. Six of the 7 patients underwent surgical resection of the recurrence. All received radiotherapy to a dose of 45 to 66 Gy. At a median follow-up of 2 years from the time of the port-site recurrence, the rate of disease-free survival at 1 and 2 years after the recurrence was 100% and 44%, respectively. The rate of local control and overall survival at 2 years was 100%.</p> </sec> <sec> <title>Conclusions</title> <p>Isolated port-site metastases in the setting of endometrial cancer are associated with high rates of local control when treated with multimodality therapy including radiotherapy. Long-term disease-free outcomes in some patients suggest the potential for cure and justify aggressive local therapy. The optimal integration of surgery, chemotherapy, and radiation is unknown.</p> </sec> </abstract>