The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval. (June 2015)

• Record Type: Journal Article
• Authors: Dingley, John; Liu, Xun; Gill, Hannah; Smit, Elisa; Sabir, Hemmen; Tooley, James; Chakkarapani, Ela; Windsor, David; Thoresen, Marianne
• Is Part Of: Anesthesia & analgesia. Volume 120:Number 6(2015)
• Publication Date: 2015-06
• Subjects: Anesthesiology -- Periodicals; Anesthesia; Anesthesiology; Analgesia; Analgesics; Anesthesiology -- Periodicals; 617.9605
• DOI: 10.1213/ANE.0000000000000693
• Languages: English
• ISSNs: 0003-2999

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>BACKGROUND:</title> <p>Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.</p> </sec> <sec> <title>METHODS:</title> <p>During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.</p> </sec> <sec> <title>RESULTS:</title> <p>Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5–193.2) (median [interquartile range]), after circuit priming (1300 mL).</p> </sec> <sec> <title>CONCLUSIONS:</title> <p>Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.</p> </sec> </abstract>