Three-weekly oxaliplatin combined with gemcitabine and capecitabine in the first-line treatment of patients with advanced biliary tract cancer. Issue 6 (July 2015)

• Record Type: Journal Article
• Authors: Petrioli, Roberto; Roviello, Giandomenico; Fiaschi, Anna I.; Laera, Letizia; Roviello, Franco; Marrelli, Daniele; Francini, Edoardo
• Is Part Of: Anti-cancer drugs. Volume 26:Issue 6(2015)
• Publication Date: 2015-07
• Subjects: Antineoplastic agents -- Periodicals; Cancer -- Chemotherapy -- Periodicals; Antineoplastic Agents -- therapeutic use -- Periodicals; Drug Therapy -- Periodicals; 616.994061
• DOI: 10.1097/CAD.0000000000000233
• Languages: English
• ISSNs: 0959-4973

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p>The primary objective of this study was to determine the activity and safety of 3-weekly oxaliplatin combined with gemcitabine and oral capecitabine in the first-line treatment of advanced biliary tract cancer. Treatment consisted of intravenous oxaliplatin 100 mg/m² every 3 weeks combined with intravenous gemcitabine 1000 mg/m² on days 1 and 8 and oral capecitabine 1500 mg/m² 14 days on 21 in two divided doses. Treatment was administered until progressive disease, unacceptable toxicity, or patient refusal. Thirty-seven patients were enrolled: eight patients had Eastern Cooperative Oncology Group 2 performance status at presentation. The overall response rate was 35.1% [95% confidence interval (CI): 20.2–52.5%] and the disease control rate was 72.9%. The median progression-free survival was 9.4 months (95% CI: 4.1–12.2 months) and the median overall survival was 13.8 months (95% CI: 7.7–17.1 months). There were no grade 4 toxicities. Grade 3 neutropenia occurred in 13.5% of patients and grade 3 thrombocytopenia in 10.8%. The present study suggests that 3-weekly oxaliplatin combined with gemcitabine and oral capecitabine is an active and well-tolerated chemotherapy regimen in the first-line treatment of metastatic biliary tract cancer.</p> </sec> </abstract>