Interactions in blends of dendronized polymeric nanocomposites with some common drugs. Issue 34 (20th May 2015)

• Record Type: Journal Article
• Authors: Alvarado, Nancy; Fuentes, Irma; Alegría, Luz; Sandoval, Claudia; Kortabería, Galder; Eceiza, Arantxa; Gargallo, Ligia; Leiva, Angel; Radić, Deodato
• Is Part Of: Journal of applied polymer science. Volume 132:Issue 34(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-05-20
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.42450
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Poly(diethylaminoethyl methacrylamide) (PEAM), a dendronized polymer, was synthesized according to classical procedures. Monomers and polymers were characterized by spectroscopic measurements. The results obtained were in agreement with the expected chemical structure. The phase behavior of blends of PEAM with diclofenac (DCF), ibuprofen (IBU)<bold>, </bold> and paracetamol (PCM) were studied by different experimental techniques. FT‐IR, UV‐Vis, DSC<bold>, </bold> and TGA measurements suggested important interactions between the blended components. Thermogravimetric analysis (TGA) indicated the temperature at which the dendronized polymer released a small molecule. AFM measurements and molecular dynamics (MD) simulations were used to better understand the nature of the interactions and to estimate the distance between the components of the blends to explain the interaction involved. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. <bold>2015</bold>, <italic>132</italic>, 42450.</p> </abstract>