Hydrogel Retaining Toxin‐Absorbing Nanosponges for Local Treatment of Methicillin‐Resistant Staphylococcus aureus Infection. (30th April 2015)

• Record Type: Journal Article
• Authors: Wang, Fei; Gao, Weiwei; Thamphiwatana, Soracha; Luk, Brian T.; Angsantikul, Pavimol; Zhang, Qiangzhe; Hu, Che‐Ming J.; Fang, Ronnie H.; Copp, Jonathan A.; Pornpattananangkul, Dissaya; Lu, Weiyue; Zhang, Liangfang
• Is Part Of: Advanced materials. Volume 27:Number 22(2015)
• Page Start: 3437
• Page End: 3443
• Publication Date: 2015-04-30
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201501071
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201501071-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A hybrid nanomaterial</bold> integrating unique toxin‐absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin‐resistant <italic>Staphylococcus aureus</italic> (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge–hydrogel hybrid show markedly reduced MRSA skin lesion development. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjrk4gz1m" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>