Bone tissue modelling and remodelling following guided bone regeneration in combination with biphasic calcium phosphate materials presenting different microporosity. Issue 7 (5th March 2014)

• Record Type: Journal Article
• Authors: Dahlin, Christer; Obrecht, Marcel; Dard, Michel; Donos, Nikos
• Is Part Of: Clinical oral implants research. Volume 26:Issue 7(2015:Jul.)
• Page Start: 814
• Page End: 822
• Publication Date: 2014-03-05
• Subjects: Dental implants -- Research -- Periodicals; 617.69
• DOI: 10.1111/clr.12361
• Languages: English
• ISSNs: 0905-7161

Abstract

<abstract abstract-type="main" id="clr12361-abs-0001"> <title>Abstract</title> <sec id="clr12361-sec-0001" sec-type="section"> <title>Objectives</title> <p>The aim of this study was to investigate bone regeneration following application of a novel biphasic calcium phosphate (BCP I) composed of microstructured granules of 90% β‐tricalcium phosphate (β‐TCP)/10% hydroxyapatite (HA) compared to BCP non‐microstructured biphasic calcium phosphate with a composite of 60% hydroxyapatite/40% β‐TCP (BCP II) and a deproteinized bovine bone mineral (DBBM) at surgically created defects in the mandible of minipigs in a combined approach with guided bone regeneration (GBR).</p> </sec> <sec id="clr12361-sec-0002" sec-type="section"> <title>Material and methods</title> <p>Sixteen minipigs were used for the study. Lower premolars P2, P3, P4 and first molar M1 were extracted. Following 3 months of healing, two defects with a width and depth of 7 mm were created bilaterally in the mandible. The different grafting materials were randomly placed in the created defects and covered by means of a collagen membrane. After 3 and 8 weeks, biopsies were sampled. All specimens were evaluated with descriptive histology and histomorphometric evaluations complemented by micro‐CT scan analysis.</p> </sec> <sec id="clr12361-sec-0003" sec-type="section"> <title>Results</title> <p>All three biomaterials presented with higher bone volume at 8 weeks compared to 3 weeks (<italic>P</italic> < 0.0442). BCP I and DBBM demonstrated a significant higher amount of bone formation compared to BCP II at 8 weeks (<italic>P</italic> < 0.0328). BCP I also demonstrated a significant higher percentage of remaining graft volume compared to the other test groups both at 3 and 8 weeks (<italic>P</italic> < 0.0001 to <italic>P</italic> < 0.0003). Congruently, defects containing BCP I showed a significant higher amount of mineralized tissue compared to the other groups.</p> </sec> <sec id="clr12361-sec-0004" sec-type="section"> <title>Conclusions</title> <p>All the three test materials performed well with regard to bone formation at 8 weeks. BCP I showed significant higher amounts of newly formed bone despite a higher remaining graft volume compared to the other groups. With regard to the regenerative outcome, all the three materials can be recommended for clinical use.</p> </sec> </abstract>