Association of mitochondrial DNA displacement loop polymorphisms and aggressive periodontitis in a Chinese population: a pilot study. (June 2015)

• Record Type: Journal Article
• Authors: Wang, Xiaoxuan; Guo, Yuan; Luan, Qingxian
• Is Part Of: Mitochondrial DNA. Volume 26:Number 3(2015:Jun.)
• Page Start: 389
• Page End: 395
• Publication Date: 2015-06
• Subjects: Mitochondrial DNA -- Periodicals; Mitochondrial DNA -- Abnormalities -- Periodicals; Nucleotide sequence -- Periodicals; Gene mapping -- Periodicals; 572.869
• DOI: 10.3109/19401736.2013.840589
• Languages: English
• ISSNs: 1940-1736

Abstract

<abstract> <title>Abstract</title> <p>To examine whether certain mitochondrial DNA (mtDNA) haplogroups and/or alterations affect susceptibility to aggressive periodontitis (AgP), we analyzed the mtDNA D-Loop region in a Han Chinese population. The mtDNA haplogroups were analyzed in 58 patients with AgP and 50 periodontally healthy controls. The frequency of haplogroups A in AgP group was significantly higher than that in the control group (<italic>p</italic> = 0.007). Furthermore, the frequency of haplogroup D was higher in the control group than that in AgP group (<italic>p</italic> = 0.007). The frequencies of D-Loop polymorphisms m.16126T &gt; C, m.16290C &gt; T and m.152 T &gt; C were significantly higher in patients with AgP compared with controls (<italic>p</italic> = 0.029, 0.014 and 0.022, respectively). Additionally, the frequencies of three other D-Loop polymorphisms, m.16223C &gt; T m.489 T &gt; C and m.515CA deletion (del) were significantly lower in patients with AgP compared with controls (<italic>p</italic> = 0.042, 0.003 and 0.026, respectively). Our study showed for the first time, an association between AgP and mtDNA haplogroups. Haplogroups A was implicated as a risk factor for AgP, while haplogroups D exhibited a protective effect in this disease. These observations may provide a new perspective on the study of the pathogenesis of periodontitis.</p> </abstract>