Correlation of rheological parameters in maternal and fetal blood at term. (May 2015)

• Record Type: Journal Article
• Authors: Csorba, Roland; Soliman, Amr A.; Wieg, Christian; Tsikouras, Panagiotis; Rath, Werner; von Tempelhoff, Georg-Friedrich
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 28:Number 8(2015)
• Page Start: 969
• Page End: 976
• Publication Date: 2015-05
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2014.939626
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: An association between maternal and fetal blood rheology has not yet been investigated nor is it known whether and to what extent fetal blood rheology may be affected by maternal conditions.</p> <p> <italic>Methods</italic>: At delivery, blood was drawn from the cubital vein of 4985 consecutive mothers and from the umbilical cord during birth for determination of blood rheological parameters (erythrocyte aggregation stasis [E0], low shear [E1], plasma viscosity [Pv]) in addition to hemoglobin (Hb) values and hematocrit (Hct).</p> <p> <italic>Results</italic>: Maternal and newborn Pv (<italic>r</italic> = 0.2; <italic>p</italic> < 0.0001) correlated statistically significant. There was a remarkable correlation between fetal Pv and gestational age (<italic>r</italic> = 0.197; <italic>p</italic> < 0.001). Iron supplementation during pregnancy led to increased fetal Hb, Hct as well as E0 and E1 (<italic>p</italic> < 0.0001), did not have a significant impact on neonatal Pv (<italic>p</italic> = 0.068). Smoking mothers gave birth to neonates with significantly higher Pv (<italic>p</italic> = 0.049), E0 (<italic>p</italic> = 0.016) and E1 (<italic>p</italic> = 0.013).</p> <p> <italic>Conclusions</italic>: The increase of fetal plasma viscosity at advanced delivery time-points refers to a more gaining protein synthesis by the fetal liver and thus maturity of the fetus. Iron supplementation as well as smoking during pregnancy is associated with a relative hyper-viscosity in the fetus at delivery.</p> </abstract>