ADIPOQ polymorphism rs182052 is associated with clear cell renal cell carcinoma. Issue 6 (24th April 2015)

• Record Type: Journal Article
• Authors: Zhang, Guiming; Gu, Chengyuan; Zhu, Yao; Luo, Lei; Dong, Dahai; Wan, Fangning; Zhang, Hailiang; Shi, Guohai; Sun, Lijiang; Ye, Dingwei
• Is Part Of: Cancer science. Volume 106:Issue 6(2015:Jun.)
• Page Start: 687
• Page End: 691
• Publication Date: 2015-04-24
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.12664
• Languages: English
• ISSNs: 1347-9032

Abstract

<abstract abstract-type="main" id="cas12664-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Recent studies have indicated that low circulating adiponectin concentrations are associated with a higher risk of several cancers, including renal cell carcinoma. In this case–control study, we examined the frequency of single nucleotide polymorphisms (rs182052G>A, rs266729C>G, and rs3774262G>A) in the adiponectin gene (<italic>ADIPOQ</italic>) in 1004 patients with clear cell renal cell carcinoma (ccRCC) compared with a group of healthy subjects (<italic>n </italic>= 1108). Fasting serum adiponectin concentrations were also examined. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). The association of serum adiponectin concentration with genetic variants was calculated using a multivariate linear regression model. A significantly higher ccRCC risk was associated with the rs182052 variant A allele (adjusted OR, 1.36 and 95% CI, 1.07–1.74 for AA <italic>vs </italic>GG, <italic> P </italic>= 0.013; adjusted OR, 1.27 and 95% CI, 1.04–1.56 for AA <italic>vs </italic>GG+AG, <italic> P </italic>= 0.019), and this positive association was more evident in overweight subjects. Fasting serum adiponectin was lower in subjects carrying A alleles of rs182052 in both ccRCC patients (β = −0.399, <italic>P </italic>= 0.018) and healthy controls (β = −0.371, <italic>P </italic>= 0.024). These results suggest that <italic>ADIPOQ</italic> rs182052 is significantly associated with ccRCC risk.</p> </abstract>