Basement membrane protein nidogen-1 is a target of meprin β in cisplatin nephrotoxicity. Issue 2 (16th July 2015)

• Record Type: Journal Article
• Authors: Herzog, Christian; Marisiddaiah, Raju; Haun, Randy S.; Kaushal, Gur P.
• Is Part Of: Toxicology letters. Volume 236:Issue 2(2015)
• Page Start: 110
• Page End: 116
• Publication Date: 2015-07-16
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.05.005
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0045"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Basement membrane protein nidogen-1 is cleaved in cisplatin-induced nephrotoxicity.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Meprin inhibitor actinonin abolished nidogen-1 cleavage during cisplatin nephrotoxicity.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Meprin β-KO mice subjected to cisplatin nephrotoxicity prevented nidogen-1 cleavage.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">This study provides the first <italic>in vivo</italic> evidence of nidogen-1 cleavage by meprin β and a pathophysiological link between meprin β and nidogen-1 in cisplatin nephrotoxicity.</p> </list-item> </list> </p> </sec> </abstract>