Association between the aldehyde dehydrogenase 2*2 allele and smoking-related chronic airway obstruction in a Japanese general population: A pilot study. Issue 2 (16th July 2015)

• Record Type: Journal Article
• Authors: Morita, Kazunori; Masuda, Natsuki; Oniki, Kentaro; Saruwatari, Junji; Kajiwara, Ayami; Otake, Koji; Ogata, Yasuhiro; Nakagawa, Kazuko
• Is Part Of: Toxicology letters. Volume 236:Issue 2(2015)
• Page Start: 117
• Page End: 122
• Publication Date: 2015-07-16
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.05.007
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0105"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Aldehyde dehydrogenase 2 (ALDH2) may protect airways against cigarette smoke injury.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010"> <italic>ALDH2*2</italic> allele and ever smoking affected airway obstruction in a dose-dependent manner.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Pack-years smoking was a predictor of airway obstruction only in <italic>*2</italic> allele carriers.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020"> <italic>*2</italic> allele is associated with the incidence of smoking-related airway obstruction.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Combined effect of smoking and <italic>*2</italic> allele was prominent in the asthmatic subjects.</p> </list-item> </list> </p> </sec> </abstract>