The Myeloid U937 Skin Sensitization Test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization. Issue 5 (August 2015)

• Record Type: Journal Article
• Authors: Piroird, Cécile; Ovigne, Jean-Marc; Rousset, Françoise; Martinozzi-Teissier, Silvia; Gomes, Charles; Cotovio, José; Alépée, Nathalie
• Is Part Of: Toxicology in vitro. Volume 29:Issue 5(2015)
• Page Start: 901
• Page End: 916
• Publication Date: 2015-08
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.03.009
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st110">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0330">Non-animal data for skin sensitization risk assessment are urgently needed.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0335">L'Oreal led to the development of the Myeloid U937 Skin Sensitization Test (U-SENS™).</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0340">Evaluation was performed of a total of 175 substances.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0345">Predictive performance was assessed by comparing U-SENS™ with human and LLNA data.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0350">Transferability and reproducibility was assessed through a ring study trial.</p> </list-item> </list> </p> </sec> </abstract>