Targeted omics analyses, and metabolic enzyme activity assays demonstrate maintenance of key mucociliary characteristics in long term cultures of reconstituted human airway epithelia. Issue 5 (August 2015)

• Record Type: Journal Article
• Authors: Baxter, Andrew; Thain, Simon; Banerjee, Anisha; Haswell, Linsey; Parmar, Aleesha; Phillips, Gary; Minet, Emmanuel
• Is Part Of: Toxicology in vitro. Volume 29:Issue 5(2015)
• Page Start: 864
• Page End: 875
• Publication Date: 2015-08
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.03.004
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st105">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0155">Characterization of long term MucilAir™ cultures to evaluate suitability for repeat-dose testing of inhaled chemicals.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0160">Airway surface liquid marker proteins are secreted in long term MucilAir™ cultures.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0165">Expression of genes coding for xenobiotics metabolizing enzymes is similar between MucilAir™ and normal lung.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0170">Activity of CYPs involved in the bioactivation of inhaled toxicants is present and maintained in long term MucilAir™ cultures.</p> </list-item> </list> </p> </sec> </abstract>