Polarized location of SLC and ABC drug transporters in monolayer-cultured human hepatocytes. Issue 5 (August 2015)

• Record Type: Journal Article
• Authors: Le Vee, Marc; Jouan, Elodie; Noel, Gregory; Stieger, Bruno; Fardel, Olivier
• Is Part Of: Toxicology in vitro. Volume 29:Issue 5(2015)
• Page Start: 938
• Page End: 946
• Publication Date: 2015-08
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.03.019
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st070">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0115">Monolayer-cultured human hepatocytes retain notable drug transporter mRNA expression.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0120">OATPs, OCT1 and MRP3 are detected at the sinusoidal pole of cultured hepatocytes.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0125">P-glycoprotein and MRP2 are expressed at the canalicular pole of cultured hepatocytes.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0130">Uptake transport is maintained in long-term monolayer-cultured human hepatocytes.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0135">Canalicular secretion is maintained in 10 day monolayer-cultured human hepatocytes.</p> </list-item> </list> </p> </sec> </abstract>