Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices. Issue 5 (August 2015)

• Record Type: Journal Article
• Authors: Vatakuti, Suresh; Schoonen, Willem G.E.J.; Elferink, Marieke L.G.; Groothuis, Geny M.M.; Olinga, Peter
• Is Part Of: Toxicology in vitro. Volume 29:Issue 5(2015)
• Page Start: 1012
• Page End: 1020
• Publication Date: 2015-08
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.03.015
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st120">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0180">PCLS is validated as a model to identify early gene expression changes related to fibrosis.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0185">Early fibrosis related genes are regulated in CCl₄, but not in APAP treated PCLS.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0190">Predicted upstream regulators in PCLS due to CCl₄ treatment are related to fibrosis.</p> </list-item> </list> </p> </sec> </abstract>