Hepatotoxicity of piperazine designer drugs: Comparison of different in vitro models. Issue 5 (August 2015)

• Record Type: Journal Article
• Authors: Dias-da-Silva, D.; Arbo, M.D.; Valente, M.J.; Bastos, M.L.; Carmo, H.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 5(2015)
• Page Start: 987
• Page End: 996
• Publication Date: 2015-08
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.04.001
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st120">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0190">TFMPP was the most cytotoxic derivative.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0195">Primary hepatocytes were the most sensitive <italic>in vitro</italic> model.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0200">CYP450-mediated metabolism contributes to the detoxification.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0205">Reactive species, GSH and ATP depletion, loss of Δ<italic>ψm</italic> and caspase-3 activation were observed.</p> </list-item> </list> </p> </sec> </abstract>