Ex vivo aorta patch model for analysis of cellular adhesion. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Lin, Yuan-Na; Thata, Raymond Nqobizitha; Failla, Antonio Virgilio; Geissen, Markus; Daum, Guenter; Windhorst, Sabine
• Is Part Of: Tissue & cell. Volume 47:Issue 3(2015)
• Page Start: 266
• Page End: 272
• Publication Date: 2015-06
• Subjects: Cytology -- Periodicals; 571.5
• DOI: 10.1016/j.tice.2015.03.004
• Languages: English
• ISSNs: 0040-8166

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0035"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0105">Here we present a new model to study cell–endothelium interaction onto an intact endothelial cell layer by plating HCT-116 cells onto mouse aortic patches.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0110">Validation of this model was performed by demonstrating changes in cell shape and development of cell protrusions typical for cell spreading.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0115">A major advantage of this model is that cell–endothelium interaction and its molecular backgrounds can now be studied more feasibly on an intact and native tissue.</p> </list-item> </list> </p> </sec> </abstract>