The development of cisplatin resistance in neuroblastoma is accompanied by epithelial to mesenchymal transition in vitro. Issue 2 (10th August 2015)

• Record Type: Journal Article
• Authors: Piskareva, Olga; Harvey, Harry; Nolan, John; Conlon, Ross; Alcock, Leah; Buckley, Patrick; Dowling, Paul; O'Sullivan, Finbarr; Bray, Isabella; Stallings, Raymond L.
• Is Part Of: Cancer letters. Volume 364:Issue 2(2015)
• Page Start: 142
• Page End: 155
• Publication Date: 2015-08-10
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.05.004
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Cisplatin induced cross resistance to temozolomide, etoposide and irinotecan.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Proteomic profiling of three cisplatin resistant neuroblastoma cell sublines.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Altered proteins had cellular growth and proliferation, cell death and survival classifications.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Increased migration of SK-N-ASCis24 correlates with elevated levels of MYH9 and ACTN4.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">EMT and increased cell migration are associated with drug resistance in SK-N-ASCis24.</p> </list-item> </list> </p> </sec> </abstract>