Interleukin-8 upregulates integrin β3 expression and promotes estrogen receptor-negative breast cancer cell invasion by activating the PI3K/Akt/NF-κB pathway. Issue 2 (10th August 2015)

• Record Type: Journal Article
• Authors: Shao, Nan; Lu, Zhenhai; Zhang, Yunjian; Wang, Mian; Li, Wen; Hu, Ziye; Wang, Shenming; Lin, Ying
• Is Part Of: Cancer letters. Volume 364:Issue 2(2015)
• Page Start: 165
• Page End: 172
• Publication Date: 2015-08-10
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.05.009
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Integrin β3 and IL-8 expression was inversely correlated with ER status in breast cancer.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">IL-8 siRNA decreased the invasion and integrin β3 expression in breast cancer cells.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">IL-8 siRNA attenuated the phosphorylation of PI3K and Akt.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">IL-8 siRNA inhibited NF-κB transcriptional activity.</p> </list-item> </list> </p> </sec> </abstract>