T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Raphael, Itay; Nalawade, Saisha; Eagar, Todd N.; Forsthuber, Thomas G.
• Is Part Of: Cytokine. Volume 74:Issue 1(2015)
• Page Start: 5
• Page End: 17
• Publication Date: 2015-07
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2014.09.011
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st050">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0230">T helper (Th) cells provide host defense, but can also promote autoimmune diseases.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0235">The original description of Th subsets considered Th1 and Th2 cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0240">New Th subsets have since been described including Th17, Th22, Th9, and Treg cells.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0245">Th subsets have been defined based on their "signature" cytokine profiles.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0250">New models of Th subset biology may have to incorporate T cell subset plasticity.</p> </list-item> </list> </p> </sec> </abstract>