Anti-hyperlipidemic effect of methanol bark extract of Terminalia chebula in male albino Wistar rats. (August 2015)

• Record Type: Journal Article
• Authors: Reddy, Murali Mohan; Dhas Devavaram, Jackson; Dhas, Jebasingh; Adeghate, Ernest; Starling Emerald, Bright
• Is Part Of: Pharmaceutical biology. Volume 53:Number 8(2015:Aug.)
• Page Start: 1133
• Page End: 1140
• Publication Date: 2015-08
• Subjects: Pharmacognosy -- Periodicals; Materia medica, Vegetable -- Periodicals; 615.321
• DOI: 10.3109/13880209.2014.962058
• Languages: English
• ISSNs: 1388-0209

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects.</p> <p> <italic>Objective</italic>: <italic>Terminalia chebula</italic> Retz. (Combretaceae) is a plant used to treat cardiac disorders in the traditional Ayurveda medicine in India. The objective of this study was to assess the anti-hyperlipidemic properties of a methanol (MeOH) bark extract of <italic>T. chebula</italic>.</p> <p> <italic>Materials and methods</italic>: Acute toxicity studies were performed according to the Organisation for Economic Cooperation and Development (OECD) guideline no. 423 using various doses (5, 50, 300, and 2000 mg/kg) of <italic>T. chebula</italic> bark. Anti-hyperlipidemic effect of MeOH bark extract of <italic>T. chebula</italic> at doses of 200, 400, and 600 mg/kg and fasting glucose levels after treatment with MeOH bark extract of <italic>T. chebula</italic> at doses of 200, 400, and 600 mg/kg were analyzed using commercially available kits.</p> <p> <italic>Results</italic>: Acute toxicity studies did not show any morbidity and mortality at various doses. The MeOH extract of <italic>T. chebula</italic> bark at doses of 200, 400, and 600 mg/kg significantly lowered serum cholesterol and triglyceride levels. Moreover, the extract of <italic>T. chebula</italic> and the positive control atorvastatin-treated groups of animals showed a significant increase in the serum high-density lipoprotein (HDL) cholesterol levels in diet-induced hypercholesterolemic animals.</p> <p> <italic>Conclusion</italic>: The overall results confirm that the bark extract of <italic>T. chebula</italic> possesses significant anti-hyperlipidemic activity.</p> </abstract>