Association of longitudinal fractional exhaled nitric oxide measurements with asthma control in atopic children. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Yang, Sohyoung; Park, Joohyun; Lee, Youn Kyung; Kim, Heon; Hahn, Youn-Soo
• Is Part Of: Respiratory medicine. Volume 109:Issue 5(2015)
• Page Start: 572
• Page End: 579
• Publication Date: 2015-05
• Subjects: Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2015.03.003
• Languages: English
• ISSNs: 0954-6111

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <title id="sectitle0015">Objectives</title> <p id="abspara0010">We sought to determine whether longitudinal measurements of FeNO are informative for future loss of asthma control in children with atopic asthma.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">One hundred seventy-eight patients aged 8–16 years with atopic asthma were enrolled. FeNO and lung functions were serially monitored 10 times or more over 2 years when subjects were not receiving controller medications. After completion of monitoring, 1-year observation on the occurrence of loss of asthma control was performed and associations of loss of asthma control with spirometric and FeNO measurements were analyzed.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Loss of asthma control occurred during observation periods in 110 (76%) of 145 patients who completed the study. Of all monitored parameters including airway reactivity, the highest FeNO of serial measurements (H-FeNO) (adjusted odds ratio (aOR), 1.21; 95% CI, 1.08–1.36) and the rate of FeNO levels higher than 21 ppb (R<sub>21</sub>FeNO) (aOR, 1.06; 95% CI, 1.01–1.11) were the only independent predictors of upcoming control loss in the multiple logistic regression analysis. In receiver-operator characteristic curve analysis, H-FeNO > 37 ppb and R<sub>21</sub>FeNO > 20% demonstrated 91% and 88% sensitivity for a future loss of asthma control at the cost of low specificity (60% and 65%, respectively). In contrast, H-FeNO > 47 ppb and R<sub>21</sub>FeNO > 41% gave 96% and 88% specificity, but these sacrificed sensitivity to 70% and 72%, respectively.</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">Our data show that both amount and frequency of a FeNO increase during longitudinal monitoring are helpful in predicting asthma control status.</p> </sec> </abstract>