Carbon‐11 Radiolabelling of Organosulfur Compounds: 11C Synthesis of the Progesterone Receptor Agonist Tanaproget. Issue 25 (12th May 2015)

• Record Type: Journal Article
• Authors: Haywood, Tom; Kealey, Steven; Sánchez‐Cabezas, Santiago; Hall, James J.; Allott, Louis; Smith, Graham; Plisson, Christophe; Miller, Philip W.
• Is Part Of: Chemistry. Volume 21:Issue 25(2015)
• Page Start: 9034
• Page End: 9038
• Publication Date: 2015-05-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201501089
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Herein a new ¹¹C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, ¹¹CS₂, is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [¹¹C]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with ¹¹CS₂, which has potential applications as a positron emission tomography radioligand for cancer imaging.</p> </abstract>