Assessment of coagulation utilizing thromboelastometry in dogs undergoing orthopedic surgery. (2nd April 2015)

• Record Type: Journal Article
• Authors: Bruno, Barbara; Maurella, Cristiana; Falco, Sara; Tarducci, Alberto; Zanatta, Renato; Gianella, Paola; D'Angelo, Antonio; Piras, Lisa; Di Bella, Andrea; Borrelli, Antonio
• Is Part Of: Journal of veterinary emergency and critical care. Volume 25:Number 3(2015:May/Jun.)
• Page Start: 358
• Page End: 363
• Publication Date: 2015-04-02
• Subjects: Veterinary emergencies -- Periodicals; Veterinary critical care -- Periodicals; 636.089
• DOI: 10.1111/vec.12300
• Languages: English
• ISSNs: 1479-3261

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="vec12300-sec-0010" sec-type="section"> <title>Objective</title> <p>To evaluate blood coagulation using thromboelastometry in dogs following orthopedic surgery.</p> </sec> <sec id="vec12300-sec-0020" sec-type="section"> <title>Design</title> <p>Longitudinal observational study.</p> </sec> <sec id="vec12300-sec-0030" sec-type="section"> <title>Setting</title> <p>University veterinary teaching hospital.</p> </sec> <sec id="vec12300-sec-0040" sec-type="section"> <title>Animals</title> <p>Thirty‐four adult client‐owned dogs.</p> </sec> <sec id="vec12300-sec-0050" sec-type="section"> <title>Measurements and Main Results</title> <p>Dogs undergoing elective or emergency orthopedic surgery had whole blood collected before (T0), at 24 hours (T1), and 1 week (T2) after surgery. Whole blood from each dog was collected by jugular venipuncture using a 20‐Ga needle and minimum venous stasis. The blood was placed into tubes containing 3.8% trisodium citrate (1 part citrate: 9 parts blood) and rested at 37°C. Coagulation was evaluated by means of thromboelastometry using the in‐TEM, ex‐TEM, and fib‐TEM assays. Statistically significant increases (<italic>P</italic> < 0.05) in maximum clot firmness (MCF) from T0 to T1 in the in‐TEM and fib‐TEM profiles (both <italic>P</italic> = 0.0001), from T0 to T2 in the in‐TEM, ex‐TEM, and fib‐TEM profiles (<italic>P</italic> = 0.012, <italic>P</italic> = 0.037, and <italic>P</italic> = 0.0001, respectively), and from T1 to T2 in the fib‐TEM profile (<italic>P</italic> = 0.039) were noted. The α angle increased from T0 to T2 in the in‐TEM and ex‐TEM profiles (<italic>P</italic> = 0.019 and <italic>P</italic> = 0.036, respectively). All results were, however, within the institutional reference ranges.</p> </sec> <sec id="vec12300-sec-0060" sec-type="section"> <title>Conclusions</title> <p>In this study, unlike the hypercoagulability observed in human orthopedic patients, a hypercoagulable state as measured by thromboelastometry did not develop in dogs following orthopedic surgery.</p> </sec> </abstract>