Association of Toll‐like Receptor 4 Gene polymorphisms with susceptibility to type 2 diabetes mellitus in the Chinese population Toll样受体4基因多态性与中国人群2型糖尿病易感性的关联研究. (3rd October 2014)

• Record Type: Journal Article
• Authors: Peng, Danfeng; Jiang, Feng; Zhang, Rong; Tang, Shanshan; Chen, Miao; Yan, Jing; Sun, Xue; Luo, Yi; Hu, Cheng; Jia, Weiping
• Is Part Of: Journal of diabetes. Volume 7:Number 4(2015:Oct.)
• Page Start: 485
• Page End: 492
• Publication Date: 2014-10-03
• Subjects: Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12206
• Languages: English
• ISSNs: 1753-0393

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jdb12206-sec-0001" sec-type="section"> <title>Background</title> <p>Toll‐like receptor 4 (TLR4) plays an important role in innate immunity. Activation of innate immune response and subsequent chronic low‐grade inflammation are thought to be involved in the pathogenesis of type 2 diabetes. In this study, we aimed to investigate the association of <italic>TLR4</italic> variants with type 2 diabetes in the Chinese population.</p> </sec> <sec id="jdb12206-sec-0002" sec-type="section"> <title>Methods</title> <p>Seven tag single nucleotide polymorphisms (SNPs) of <italic>TLR4</italic> based on HapMap Chinese data were genotyped in the Shanghai Chinese, including 3404 type 2 diabetes patients and 3401 controls. The controls were extensively phenotyped for the traits related to glucose metabolism and insulin secretion.</p> </sec> <sec id="jdb12206-sec-0003" sec-type="section"> <title>Results</title> <p>In total participants, we identified that rs10759932 and rs1927911 were associated with type 2 diabetes (odds ratio 1.106, <italic>P</italic> = 0.009 for rs10759532, odds ratio 1.092, <italic>P</italic> = 0.013 for rs1927911). rs11536889 showed a trend association with type 2 diabetes (odds ratio 0.957, <italic>P</italic> = 0.057). This SNP was also associated with 2‐h plasma glucose (<italic>P</italic> = 0.033) and high‐density lipoprotein‐cholesterol (<italic>P</italic> = 0.031). In female participants, rs10759932, rs1927911 and rs11536889 were associated with type 2 diabetes (odds ratio 1.176, <italic>P</italic> = 0.002 for rs10759932, odds ratio 1.136, <italic>P</italic> = 0.009 for rs1927911, odds ratio 0.882, <italic>P</italic> = 0.024 for rs11536889). Besides, rs11536889 was significantly associated with 2‐h plasma glucose (<italic>P</italic> = 0.050) and HOMA‐B (<italic>P</italic> = 0.046) with adjusting for age and body mass index in female normal subjects.</p> </sec> <sec id="jdb12206-sec-0004" sec-type="section"> <title>Conclusions</title> <p>We conclude that genetic variants of <italic>TLR4</italic> are associated with type 2 diabetes in the Chinese population, especially in female subjects.</p> </sec> </abstract>