Factor H-related proteins determine complement-activating surfaces. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Józsi, Mihály; Tortajada, Agustin; Uzonyi, Barbara; Goicoechea de Jorge, Elena; Rodríguez de Córdoba, Santiago
• Is Part Of: Trends in immunology. Volume 36:Issue 6(2015)
• Page Start: 374
• Page End: 384
• Publication Date: 2015-06
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2015.04.008
• Languages: English
• ISSNs: 1471-4906

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The role of Factor H-related proteins (FHRs) is poorly understood and controversial.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">First considered complement inhibitors, new data show FHRs enhance activation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">FHRs antagonize FH regulation; an activity denominated complement de-regulation.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">FHRs provide improved discrimination of the self and non-self/foreign surfaces.</p> </list-item> </list> </p> </sec> </abstract>