Regular aspirin use and stomach cancer risk in China. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Wang, Y.; Shen, C.; Ge, J.; Duan, H.
• Is Part Of: European journal of surgical oncology. Volume 41:Issue 6(2015:Jun.)
• Page Start: 801
• Page End: 804
• Publication Date: 2015-06
• Subjects: Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2015.02.006
• Languages: English
• ISSNs: 0748-7983

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objective</title> <p id="abspara0010">Epidemiological studies on aspirin and stomach cancer have been inconclusive. The purpose of our study was to investigate the association between aspirin and stomach cancer in China.</p> </sec> <sec> <title id="sectitle0020">Method</title> <p id="abspara0015">A 1:2 matched case–control study was conducted in four large medical centers. A self-designed questionnaire was used to collect information. Unconditional logistic regression was used to compute crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).</p> </sec> <sec> <title id="sectitle0025">Result</title> <p id="abspara0020">Our study indicated that risk of stomach cancer was greatly reduced for regular aspirin user (OR = 0.62; 95% CI 0.42–0.80). Specifically, dosage and tablet-years of use were associated with lower risk (OR = 0.54; 95% CI 0.29–0.84 for ≥7 tabs/week; OR = 0.47; 95% CI 0.32–0.81 for ≥10 tablet years, respectively). Furthermore, the finding was strengthened by stratified studies of gender, smoking status, body mass index (BMI) and helicobacter pylori.</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">Our study confirmed that regular aspirin use is a protective factor to stomach cancer.</p> </sec> </abstract>