Extra-pulmonary small cell carcinoma in the head and neck setting: The role of prophylactic cranial irradiation. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Mason, Matthew; Giuliani, Meredith; Huang, Shao Hui; Xu, Wei; Hope, Andrew; Kim, John; Bayley, Andrew; John Cho, B.C.; Goldstein, David; Jang, Raymond W; Ordonez, Bayardo Perez; Wajstaub, Sandra; Waldron, John; Dinniwell, Robert; O'Sullivan, Brian; Ringash, Jolie
• Is Part Of: Oral oncology. Volume 51:Issue 6(2015:Jun.)
• Page Start: e57
• Page End: e59
• Publication Date: 2015-06
• Subjects: Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2015.03.014
• Languages: English
• ISSNs: 1368-8375

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st015">Summary</title> <sec> <p id="sp0005">Head-and-neck small cell carcinoma (HN-SmCC) is a rare entity and there is limited data to support management decisions. The role of prophylactic cranial irradiation (PCI) remains controversial. A retrospective review of 21 consecutive HN-SmCCs was performed. No case received PCI. The 2-year overall survival, local, regional and distant control rates were 65%, 94%, 88%, and 76% respectively. Despite no patient receiving PCI, brain metastases were uncommon (<italic>n</italic> = 2) and routine use of PCI is not justified in this population.</p> </sec> </abstract>