APOBEC3 genes: retroviral restriction factors to cancer drivers. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Henderson, Stephen; Fenton, Tim
• Is Part Of: Trends in molecular medicine. Volume 21:Issue 5(2015)
• Page Start: 274
• Page End: 284
• Publication Date: 2015-05
• Subjects: Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2015.02.007
• Languages: English
• ISSNs: 1471-4914

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">APOBEC3 (A3) enzymes deaminate single-stranded DNA, mutating viral genomes.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Tumors harbor mutations likely due to off-target A3 deamination of chromosomal DNA.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">A common <italic>APOBEC3</italic> deletion polymorphism increases breast cancer risk.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">A growing body of evidence points to a driver role for APOBEC3s in tumorigenesis.</p> </list-item> </list> </p> </sec> </abstract>