Codification of bidentate pMHC interaction with TCR and its co-receptor. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Reinherz, Ellis L.; Wang, Jia-huai
• Is Part Of: Trends in immunology. Volume 36:Issue 5(2015)
• Page Start: 300
• Page End: 306
• Publication Date: 2015-05
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2015.03.004
• Languages: English
• ISSNs: 1471-4906

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Functional data implying conjoint TCR and co-receptor binding to pMHC have been structurally established.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Binding modes of CD4 and CD8 to pMHCII and pMHCI, respectively, are distinct.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Mechanobiology has an important role in the TCR–pMHC interaction.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Mechanical force during the TCR–pMHC interaction may optimize exposure of the co-receptor binding site on MHC.</p> </list-item> </list> </p> </sec> </abstract>