Investigating the pharmacokinetics and biological distribution of silver‐loaded polyphosphoester‐based nanoparticles using 111Ag as a radiotracer. (8th May 2015)

• Record Type: Journal Article
• Authors: Aweda, Tolulope A.; Zhang, Shiyi; Mupanomunda, Chiedza; Burkemper, Jennifer; Heo, Gyu Seong; Bandara, Nilantha; Lin, Mai; Cutler, Cathy S.; Cannon, Carolyn L.; Youngs, Wiley J.; Wooley, Karen L.; Lapi, Suzanne E.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 58:Number 6(2015)
• Page Start: 234
• Page End: 241
• Publication Date: 2015-05-08
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3289
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Purified <sup>111</sup>Ag was used as a radiotracer to investigate silver loading and release, pharmacokinetics, and biodistribution of polyphosphoester‐based degradable shell crosslinked knedel‐like (SCK) nanoparticles as a comparison to the previously reported small molecule, <italic>N</italic>‐heterocyclic silver carbene complex analog (SCC1) for the delivery of therapeutic silver ions in mouse models. Biodistribution studies were conducted by aerosol administration of <sup>111</sup>Ag acetate, [<sup>111</sup>Ag]SCC1, and [<sup>111</sup>Ag]SCK doses directly into the lungs of C57BL/6 mice. Nebulization of the <sup>111</sup>Ag antimicrobials resulted in an average uptake of 1.07 ± 0.12% of the total aerosolized dose given per mouse. The average dose taken into the lungs of mice was estimated to be 2.6 ± 0.3% of the dose inhaled per mouse for [<sup>111</sup>Ag]SCC1 and twice as much dose was observed for the [<sup>111</sup>Ag]SCKs (5.0 ± 0.3% and 5.9 ± 0.8% for [<sup>111</sup>Ag]aSCK and [<sup>111</sup>Ag]zSCK, respectively) at 1 h post administration (p.a.). [<sup>111</sup>Ag]SCKs also exhibited higher dose retention in the lungs; 62–68% for [<sup>111</sup>Ag]SCKs and 43% for [<sup>111</sup>Ag]SCC1 of the initial 1 h dose were observed in the lungs at 24 h p.a.. This study demonstrates the utility of <sup>111</sup>Ag as a useful tool for monitoring the pharmacokinetics of silver‐loaded antimicrobials <italic>in vivo</italic>.</p> </abstract>