Formulation of cellulose film containing permeation enhancers for prolonged delivery of propranolol hydrocloride. (June 2015)

• Record Type: Journal Article
• Authors: Bigucci, Federica; Abruzzo, Angela; Cerchiara, Teresa; Gallucci, Maria Caterina; Luppi, Barbara
• Is Part Of: Drug development and industrial pharmacy. Volume 41:Number 6(2015:Jun.)
• Page Start: 1017
• Page End: 1025
• Publication Date: 2015-06
• Subjects: Pharmaceutical chemistry -- Periodicals; Pharmaceutical industry -- Periodicals; Drug Industry -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615.05
• DOI: 10.3109/03639045.2014.925914
• Languages: English
• ISSNs: 0363-9045

Abstract

<abstract> <title>Abstract</title> <p>The aim of this study was to evaluate the capacity of cellulose films enriched with oleic acid and polysorbate 80 to enhance the transdermal permeation of propranolol hydrochloride. Polymeric films were prepared by casting and drying aqueous solutions of hydroxypropylmethylcellulose or carboxymethylcellulose and characterized in chemical–physical properties, such as drug content, thickness, morphology and water uptake capacity. <italic>In vitro</italic> transport experiments were performed in order to evaluate the permeation enhancing ability of oleic acid and polysorbate 80. All carboxymethylcellulose films showed lower cumulative amounts of drug permeated than hydroxypropylmethylcellulose. Moreover, films containing both oleic acid and polysorbate 80 provided a greater permeation in comparison to film without permeation enhancers or only with one of these. The results obtained confirm that propranolol hydrochloride permeation can be easily modulated by varying the cellulose and enhancer type used for film preparation.</p> </abstract>