Cardiovascular risk markers in patients with psoriatic arthritis: A meta-analysis of literature studies. (June 2015)

• Record Type: Journal Article
• Authors: Di Minno, Matteo Nicola Dario; Ambrosino, Pasquale; Lupoli, Roberta; Di Minno, Alessandro; Tasso, Marco; Peluso, Rosario; Tremoli, Elena
• Is Part Of: Annals of medicine. Volume 47:Number 4(2015)
• Page Start: 346
• Page End: 353
• Publication Date: 2015-06
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.3109/07853890.2015.1031822
• Languages: English
• ISSNs: 0785-3890

Abstract

<abstract> <title>Abstract</title> <p> <italic>Introduction.</italic> Several studies reported an increased cardiovascular (CV) morbidity and mortality in patients with psoriatic arthritis (PsA). We performed a meta-analysis on the impact of PsA on major markers of CV risk.</p> <p> <italic>Methods</italic>. Studies on the relationship between PsA and common carotid artery intima-media thickness (CCA-IMT), prevalence of carotid plaques, flow-mediated dilation (FMD), nitrate-mediated dilation (NMD), pulse wave velocity (PWV), augmentation index (AIx), and ankle-brachial index (ABI) were systematically searched in the PubMed, Web of Science, Scopus, and EMBASE databases.</p> <p> <italic>Results</italic>. Sixteen case-control studies (898 cases, 1, 140 controls) were included. Compared to controls, PsA patients showed a higher CCA-IMT (MD 0.07 mm; 95% CI 0.04, 0.11; <italic>P</italic> < 0.0001), and a higher frequency of carotid plaques (OR 3.12; 95% CI 1.03, 9.39; <italic>P</italic> = 0.04). Moreover, a lower FMD was found in PsA subjects than in controls (MD –2.56%; 95% CI –4.17, –0.94; <italic>P</italic> = 0.002), with no differences in NMD (MD –0.40%; 95% CI –1.19, 0.39; <italic>P</italic> = 0.32). Because of the low number of studies, no meta- analytical evaluation was performed for PWV, AIx, and ABI. Despite heterogeneity among studies, PsA appears significantly associated with markers of subclinical atherosclerosis and CV risk.</p> <p> <italic>Discussion</italic>. These findings could help to establish more specific CV prevention strategies in this clinical setting.</p> </abstract>