Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases1. Issue 22 (14th June 2015)

• Record Type: Journal Article
• Authors: Pergolizzi, Giulia; Cominetti, Marco M. D.; Butt, Julea N.; Field, Robert A.; Bowater, Richard P.; Wagner, Gerd K.
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 22(2015)
• Page Start: 6380
• Page End: 6398
• Publication Date: 2015-06-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00294j
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjqwj26wk" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />2-Substituted NAD⁺ derivatives are poor substrates, but moderate inhibitors for NAD⁺-dependent bacterial DNA ligases, acting synergistically with NAD⁺.</p> </abstract>