Supramolecular Nanosubstrate‐Mediated Delivery for Reprogramming and Transdifferentiation of Mammalian Cells. Issue 21 (22nd January 2015)

• Record Type: Journal Article
• Authors: Hou, Shuang; Choi, Jin‐sil; Chen, Kuan‐Ju; Zhang, Yang; Peng, Jinliang; Garcia, Mitch A.; Yu, Jue‐Hua; Thakore‐Shah, Kaushali; Ro, Tracy; Chen, Jie‐Fu; Peyda, Parham; Fan, Guoping; Pyle, April D.; Wang, Hao; Tseng, Hsian‐Rong
• Is Part Of: Small. Volume 11:Issue 21(2015)
• Page Start: 2499
• Page End: 2504
• Publication Date: 2015-01-22
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201402602
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="smll201402602-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Supramolecular nanosubstrate‐mediated delivery</bold> (SNSMD) leverages the power of molecular self‐assembly and a nanostructured substrate platform for the low toxicity, highly efficient co‐delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal‐like cells. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjqkdr9vd" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>