A Human Clinical, Histological, Histomorphometrical, and Radiographical Study on Biphasic HA‐Beta‐TCP 30/70 in Maxillary Sinus Augmentation. (4th September 2013)

• Record Type: Journal Article
• Authors: Mangano, Carlo; Sinjari, Bruna; Shibli, Jamil A.; Mangano, Francesco; Hamisch, Sabine; Piattelli, Adriano; Perrotti, Vittoria; Iezzi, Giovanna
• Is Part Of: Clinical implant dentistry and related research. Volume 17:Number 3(2015:Jun.)
• Page Start: 610
• Page End: 618
• Publication Date: 2013-09-04
• Subjects: Dental implants -- Periodicals; Dental Implantation -- Periodicals; Dental Implants -- Periodicals; 617.693
• DOI: 10.1111/cid.12145
• Languages: English
• ISSNs: 1523-0899

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="cid12145-sec-0001" sec-type="section"> <title>Background</title> <p>By mixing hydroxyapatite (HA) and tricalcium phosphate (TCP), biphasic calcium phosphate ceramics can be obtained, and by varying their ratio it is possible to tailor the characteristics of the biomaterial.</p> </sec> <sec id="cid12145-sec-0002" sec-type="section"> <title>Purpose</title> <p>The aim of the present human study was to evaluate the histological and radiographical aspects of bone formation in maxillary sinus augmentation using a 30/70 HA‐beta‐TCP with a reticular structure.</p> </sec> <sec id="cid12145-sec-0003" sec-type="section"> <title>Materials and Methods</title> <p>A total of 12 patients, undergoing two‐stage sinus augmentation procedure using HA‐beta‐TCP at a ratio of 30/70, were included in the present study. After a 6‐month healing period, during implant insertion, radiographical analysis was performed, and then the bone core biopsies were harvested and processed for histology.</p> </sec> <sec id="cid12145-sec-0004" sec-type="section"> <title>Results</title> <p>At radiographic evaluation, the bone gain was on average 6.85 ± 0.60 mm. HA‐beta‐TCP 30/70 appeared to be lined by newly formed bone, with no gaps at the interface. The histomorphometric analysis revealed 26 ± 2% of residual grafted biomaterial, 29 ± 3% of newly formed bone, and 45 ± 2% of marrow spaces.</p> </sec> <sec id="cid12145-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The present results indicate histologically the high biocompatibility and osteoconductivity of HA‐beta‐TCP 30/70, and clinically its successful use for sinus augmentation procedures.</p> </sec> </abstract>