Asymmetric Aldol Reaction of Chloral Catalyzed by Diarylprolinol. Issue 11 (12th May 2015)

• Record Type: Journal Article
• Authors: Hayashi, Yujiro; Watanabe, Shoya; Yasui, Yusuke; Umemiya, Shigenobu
• Is Part Of: ChemCatChem. Volume 7:Issue 11(2015:Jun.)
• Page Start: 1646
• Page End: 1649
• Publication Date: 2015-05-12
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201500282
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The asymmetric cross‐aldol reaction of chloral hydrate with aldehyde pronucleophiles catalyzed by a trifluoromethyl‐substituted diarylprolinol was accomplished to afford γ‐trichloro‐β‐hydroxy aldehydes in good yields with excellent enantioselectivities. The resulting aldehyde products were converted into chiral α‐azido, α‐(4‐methyl)phenoxy, and α‐fluoro esters without a loss in the diastereo‐ or enantioselectivities.</p> </abstract>